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One way to “block” estrogen, then, would be to stop its production by inhibiting the enzyme that makes it: aromatase.
Aromatase inhibitors are used to treat a variety of different medical issues, such as infertility (lack of ovulation), gynecomastia (even by body builders because the anabolic steroids they use can be aromatized to estrogens and stimulate breast tissue growth), short stature (due to a number of different causes), genetic activation of the aromatase gene (familial gynecomastia and familial hyperestrogenism) and estrogen-sensitive breast cancer.
meera wrote: Hi, I recently met with a gyn onc and he suggested having my ovaries and possibly my uterus as well removed - more as a precaution than for any particular reason.
I am 44 and so I will most likely go into early menopause from the chemo and so he said that this will help prevent ovarian and cervical cancer and will aslo reduce the chances of BC recurrence. I was dx with stage 2a BC in January and have had a lumpectomy to remove the tumor.
I was grade 2 and told to stay with the annual mammo.
Since there is higher recurrence with lumpectomy it would seem an annual mammo would be correct course.
I researched it and thought about all my choices and decided to go ahead with a complete hystorectmy...first thing I remember coming out of recovery is my GYN telling me that I made the right decision...he removed my ovaries they were covered with cyst that we never knew about as I'd never had female troubles....there was also some thickening of the uterus as well..said that in a handful of years I would have been doing this anyway....
( removal of both testicles is known as a bilateral orchiectomy, or castration, because the person is no longer able to reproduce.Anyway, the title notwithstanding, I have been wanting to write something about the effects of sex steroids on bone ever since I saw a post by a guy on one of the lists who mentioned that his endocrinologist said that taking estrogen blockers didn’t matter. The mixed agonists/antagonists are also used to treat ER-positive breast cancer and have selective activity depending on the tissue.